Endocrine Abstracts

Introduction: Pseudohypoaldosteronism type 2 (PHA2), also known as Gordon syndrome is a rare inherited form of low-renin hypertension associated with hyperkalaemia and hyperchloremic metabolic acidosis in patients with a normal glomerular filtration rate (GFR). PHA2 is the result of mutations in a family of serine-threonine kinases called with-no-lysine kinases (WNK) 1 and WNK4. These enzymes regulate electron channels in the aldosterone sensitive distal nephron, resulting in ...